Publications

Direct Modeling of Pore Size Evolution and Microcollapse in Lyophilization by Population Balance

Posted to arXiv, 2026-10-02.

Work that resulted from my my time spent as a Fulbright grantee, doing an exchange at the Politecnico di Torino in Italy.

Citation: Isaac S. Wheeler, Vivek Narsimhan, Alina Alexeenko, Davide Fissore. Direct modeling of pore size evolution and microcollapse in lyophilization by population balance. arXiv preprint arXiv:2610.01851 (2026). doi:10.48550/arXiv.2610.01851
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A consensus framework for digital twin development in lyophilization

Published in AAPS Open, 2026

Large collaborative paper describing the state of the art and frameworks for adopting digital twins in lyophilization (that is, making feedback control possible).

Citation: Kazarin, P., Metsi-Guckel, E., Alexeenko, A., Tchessalov, S., Aglave, R., Al Bakri, W., Authelin, J.-R., Dowling, D., Ganguly, A., Gong, E., Horner, M., Fontana, L., Iyer, L., Kessler, W., Kiehl, D., Lapointe-Garant, P.-P., Longwell, G., Moussa, E., Najarian, J., Saha, K., Sebastiao, I., Shalaev, E., Tukra, R., Vorozhbit, E., Wheeler, I.S., Bhatt, S. (2026). A consensus framework for digital twin development in lyophilization. AAPS Open, 12(1), 52. https://doi.org/10.1186/s41120-026-00150-w
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Mechanistic Models with Experimental Comparison for Microwave-assisted Lyophilization in a Vial

Published in AAPS Open, 2026

Published as part of the Dr. Steven L. Nail special collection on advances in freeze drying technology.

Citation: Isaac Wheeler, Ahmad Darwish, Vivek Narsimhan, Alina Alexeenko. Mechanistic models with experimental comparison for microwave-assisted lyophilization in a vial. AAPS Open 12, 42 (2026). https://doi.org/10.1186/s41120-026-00173-3
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Randomized-Field Microwave-Assisted Pharmaceutical Lyophilization with Closed-Loop Control

Published in Scientific Reports, 2025

Citation: Alina Alexeenko, Ahmad Darwish, Drew Strongrich, Petr Kazarin, Chanakya Patil, Cole Tower, Isaac Wheeler, Eric Munson, Qi Zhou, Vivek Narsimhan, Kyu Yoon, Steven Nail, Anthony Cofer, Justin Stanbro, Harshil Renawala, Daniel Roth, Francis DeMarco, Justin Griffiths, Dimitrios Peroulis, "Randomized-Field Microwave-Assisted Pharmaceutical Lyophilization with Closed-Loop Control." Scientific Reports, 2025.
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Traffic Signal Control with Communicative Deep Reinforcement Learning Agents: A Case Study

Published in arXiv preprint, 2024

Citation: Paolo Fazzini, Marco Montuori, Isaac Wheeler, Emilio Campana, Stefano Giagu, Guido Caldarelli, Marica De, Francesco Petracchini, "Traffic Signal Control with Communicative Deep Reinforcement Learning Agents: A Case Study." arXiv preprint, 2024.
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RadLib: A Radiative Property Model Library for CFD

Published in Computer Physics Communications, 2022

Citation: Victoria Stephens, Sally Jensen, Isaac Wheeler, David Lignell, "RadLib: A Radiative Property Model Library for CFD." Computer Physics Communications, 2022.
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Ambient Cooling of a Bowl of Soup

Published in Journal of Applied Engineering Mathematics, 2020

This was the final project for a masters-level class during my undergraduate, applying a neat integral transform method to solving second-order PDEs.

Citation: Isaac Wheeler and Gabriel Meyer. " Ambient Cooling of a Bowl of Soup." Journal of Applied Engineering Mathematics, 2020
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Rarefied Porous Flow in Lyophilization: Review and Open Questions

Published in AIP Conference Proceedings, 2024

Citation: Isaac Wheeler, Vivek Narsimhan, Alina Alexeenko, "Rarefied Porous Flow in Lyophilization: Review and Open Questions." AIP Conference Proceedings, 2024.
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