Published in AAPS Open, 2026
Published as part of the Dr. Steven L. Nail special collection on advances in freeze drying technology.
Recommended citation: Isaac Wheeler, Ahmad Darwish, Vivek Narsimhan, Alina Alexeenko. Mechanistic models with experimental comparison for microwave-assisted lyophilization in a vial. AAPS Open 12, 42 (2026). https://doi.org/10.1186/s41120-026-00173-3
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Published in arXiv preprint, 2024
Recommended citation: Paolo Fazzini, Marco Montuori, Isaac Wheeler, Emilio Campana, Stefano Giagu, Guido Caldarelli, Marica De, Francesco Petracchini, "Traffic Signal Control with Communicative Deep Reinforcement Learning Agents: A Case Study." arXiv preprint, 2024.
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Published in Computer Physics Communications, 2022
Recommended citation: Victoria Stephens, Sally Jensen, Isaac Wheeler, David Lignell, "RadLib: A Radiative Property Model Library for CFD." Computer Physics Communications, 2022.
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Published in Journal of Applied Engineering Mathematics, 2020
This was the final project for a masters-level class during my undergraduate, applying a neat integral transform method to solving second-order PDEs.
Recommended citation: Isaac Wheeler and Gabriel Meyer. " Ambient Cooling of a Bowl of Soup." Journal of Applied Engineering Mathematics, 2020
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Published in AAPS Open, 2026
Large collaborative paper describing the state of the art and frameworks for adopting digital twins in lyophilization (that is, making feedback control possible).
Recommended citation: Kazarin, P., Metsi-Guckel, E., Alexeenko, A., Tchessalov, S., Aglave, R., Al Bakri, W., Authelin, J.-R., Dowling, D., Ganguly, A., Gong, E., Horner, M., Fontana, L., Iyer, L., Kessler, W., Kiehl, D., Lapointe-Garant, P.-P., Longwell, G., Moussa, E., Najarian, J., Saha, K., Sebastiao, I., Shalaev, E., Tukra, R., Vorozhbit, E., Wheeler, I.S., Bhatt, S. (2026). A consensus framework for digital twin development in lyophilization. AAPS Open, 12(1), 52. https://doi.org/10.1186/s41120-026-00150-w
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Published in Scientific Reports, 2025
Recommended citation: Alina Alexeenko, Ahmad Darwish, Drew Strongrich, Petr Kazarin, Chanakya Patil, Cole Tower, Isaac Wheeler, Eric Munson, Qi Zhou, Vivek Narsimhan, Kyu Yoon, Steven Nail, Anthony Cofer, Justin Stanbro, Harshil Renawala, Daniel Roth, Francis DeMarco, Justin Griffiths, Dimitrios Peroulis, "Randomized-Field Microwave-Assisted Pharmaceutical Lyophilization with Closed-Loop Control." Scientific Reports, 2025.
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Published in AIP Conference Proceedings, 2024
Recommended citation: Isaac Wheeler, Vivek Narsimhan, Alina Alexeenko, "Rarefied Porous Flow in Lyophilization: Review and Open Questions." AIP Conference Proceedings, 2024.
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